Deep Breath Initiative
State of the Art Breath Analysis for the Future of Health Care
 
Our Vision
DBI aims to uncover the full potential of Molecular Breath Analysis to advance precision medicine and make it available for general health care.
 
Our Mission
DBI implements Molecular Breath Analysis by combining mass-spectrometry with advanced Artificial Intelligence to turn it into a powerful platform for medical research and daily clinical practice.
 
Why Breath Analysis?
Ø Breath contains hundreds of Volatile Organic Compounds (VOC)
Ø Breath is easy and painless to collect
Ø Breath Analysis is Non-Invasive and allows real-time monitoring
 
Applications of Breath Analysis:
Ø Breath Analysis opens the door to Advancing Precision Medicine in early phase clinical research
Ø Defining dose response / Drug dose optimization to avoid / minimize toxic effects
Ø Identify Responders / Non-responders and other positive drug related effects
Ø Disease Diagnosis and Phenotype Identification
 
Methodology & Technology
We combine highly sensitive state-of-the-art high-resolution mass spectrometry with sophisticated bioinformatic tools to provide unprecedented breath metabolic profiling.
Characteristics:
ü Real-time analysis
ü Wide metabolome coverage
ü Fast & Painless
Our Core Competences:
ü Interpretation of data collected from breath
ü Connecting breath data to relevant clinical information
 
Key Reference Publications
² Gaugg M, Nussbaumer-Ochsner Y, Bregy L, Engler A, Stebler N, Gaisl T, Bruderer T, Nowak N, Sinues P, Zenobi R, Kohler M. Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations. Chest 2018.
² Gaugg M, Engler A, Bregy L, Nussbaumer-Ochsner Y, Eiffert L, Bruderer T, Zenobi R, Martinez-Lozano Sinues P, Kohler M. Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis, Respirology 2018.
² Schwarz EI, Martinez-Lozano Sinues P, Bregy L, Gaisl T, Garcia Gomez D, Gaugg MT, Suter Y, Stebler N, Nussbaumer-Ochsner Y, Bloch KE, Stradling JR, Zenobi R, Kohler M. Effects of CPAP therapy withdrawal on exhaled breath pattern in obstructive sleep apnoea. Thorax 2016; 71: 110-117.
² Li X, Martinez-Lozano Sinues P, Dallmann R, Bregy L, Hollmén M, Proulx S, Brown SA, Detmar M, Kohler M, Zenobi R. Drug pharmacokinetics determined by real-time analysis of mouse breath. Angewandte Chemie 2015; 54: 7815-7818.
Bruderer T, Gaisl T, Gaugg M, Nowak N, Streckenbach B, Müller S, Moeller A, Kohler M, Zenobi R. Online analysis of exhaled breath. Chemical Reviews 2019.